Holtzman Laboratory — Biology Department
Project background information: Orchestrating the formation of a three dimensional organ during animal development requires directed cell migration, changes in cell number, changed in cell shape and cell-cell communication to ensure this dance is properly coordinated. Proper formation of the heart requires the developing organ to respond to biophysical stresses imposed by blood flow. Our lab has identified a mutation in the atrial specific myosin (key muscle protien). This mutation severs as an excellent model for studying the role of hemodynamic forces on tissue morphogenesis.
Students will work on two key aspects of this project: 1) Assess the hemodynamic properties in wildtype, myh6 mutant embryos with partial atrial contraction and myh6 mutant embryos with no atrial contractions. 2) Determine the consequence of modified hemodynamic properties in myh6 mutants on the cell biology of the endocardium and myocardium.
Students involved in this project will learn be required to take a chemical safety training course (1.5 hours), an online ethics course (1 hour) and an online animal use in experiments training course (1 hour). They will also be expected to attend lab meeting and participate in rotating lab jobs such as fish feeding and basic lab cleaning.
Qualifications: Basic computer skills such as email, word, excel. Additional computer skills such as photoshop are helpful but not needed.
You must have completed the first year (2 semesters) of college level biology (on the Queens College campus this means Bio 105/106).
Basic experience with microscopy is helpful.
Flexible schedule with a minimum of 10 hours a week to commit to lab.
Contact for further information:
Dr. Nathalia Holtzman